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  • Nanothermia Method, advanced deep Hyperthermia

Cellumed High Clinic
Nanothermia method, a unique improvement on conventional oncological Hyperthermia, represents the next generation of Hyperthermia therapy. It selectively destroys malignant cells by applying the required specifi c energy dose. While traditional Hyperthermia functions solely via certain thermodynamic parameters, such as temperature, Nanothermia functions by controlling absorbed energy doses, via an approach similar to that used in radiation therapy. Nanothermia moves beyond conventional heat therapies by using controlled, selective energy transfer. Nanothermia transports energy directly to malignant cells, via a selecting electric fi eld. The therapy thus functions in a largely apoptotic manner. The entire treatment is controlled by the modulated electric fi eld that passes through the patient. In the process, the tumor becomes a constant, controllable parameter within a closed electric circuit.

Percentage distribution of killed cells after Hyperthermia and Nanothermia method Already at a temperature of 38°C, Oncothermia therapy yields better results than classic Hyperthermia does even at a higher temperature of 42°C. The number of killed cells is 2.5 times higher!

Apoptosis induced by Nanothermia method,  Hyperthermia treatment kills malignant cells largely via necrosis. In the process, toxins are released that can burden the immune system. Nanothermia method, on the other hand, harnesses the immune system to induce apoptotic death of malignant cells. Apoptosis pathways can be triggered and measured via ß--catenin and connexin. Apoptosis can even be retraced morphologically, although ß--catenin is the most effi cient indicator for demonstrating natural apoptotic change after 72 h .

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